Platelet-derived thrombospondin-1 is necessary for the vitamin D-binding protein (Gc-globulin) to function as a chemotactic cofactor for C5a.

Cofactor for C5a (Gc-Globulin) to Function as a Chemotactic Necessary for the Vitamin D-Binding Protein Platelet-Derived Thrombospondin-1 Is

Gc-globulin (vitamin D-binding protein) enhances the neutrophil chemotactic activity of C5a and C5a des Arg.

Several serum proteins have been shown to be important in modulating leukocyte chemotaxis and inflammation. We investigated the possibility that the multifunctional serum protein Gc-globulin (vitamin D-binding protein) may also enhance the neutrophil chemotactic activity of complement-derived peptides. Purified Gc-globulin by itself did not induce chemotaxis of human neutrophils. However, as li...

Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity.

The Gc protein (human group-specific component (Gc), a vitamin D-binding protein or Gc globulin), has important physiological functions that include involvement in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5a for neutrophils in inflammation and macrophage activation (mediated by a GalNAc-modified Gc protein (GcMAF)). In thi...

Regulation of C5a Co-Chemotactic Activity Neutrophils: A Potential Role in the D-Binding Protein (Gc-Globulin) to Elastase Controls the Binding of the Vitamin

Gc-globulin: roles in response to injury.

BACKGROUND Gc-globulin (vitamin D-binding protein) appears to have important functions in addition to its role as a carrier of vitamin D. APPROACH We reviewed recent studies focusing on the pathophysiologic functions and clinical significance of Gc-globulin. RESULTS Serum concentrations of Gc-globulin, as determined by immunoassay techniques, are decreased in severe injury. The extent of th...